自分を知り、自分を変えていく

業績

原著論文

  1. Koike K, Hashimoto K, Fukami G, Okamura N, Zhang L, Ohgake S, Koizumi H, Matsuzawa D, Kawamura N, Shimizu E, Iyo M. The immunophilin ligand FK506 protectsagainst methamphetamine-induced dopaminergic neurotoxicity in mouse striatum.Neuropharmacology. 2005;48(3):391-7.
  2. Hashimoto T, Hashimoto K, Matsuzawa D, Shimizu E, Sekine Y, Inada T, Ozaki N,Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M. A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2005;135B(1):5-9
  3. Kobayashi K, Shimizu E, Hashimoto K, Mitsumori M, Koike K, Okamura N, Koizumi H, Ohgake S, Matsuzawa D, Zhang L, Nakazato M, Iyo M. Serum brain-derived neurotrophic factor (BDNF) levels in patients with panic disorder: as a biological predictor of response to group cognitive behavioral therapy. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(5):658-63.
  4. Shimizu E, Hashimoto K, Koizumi H, Kobayashi K, Itoh K, Mitsumori M, Ohgake S, Okamura N, Koike K, Matsuzawa D, Zhang L, Kumakiri C, Nakazato M, Komatsu N, Iyo M. No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(5):708-12.
  5. Matsuzawa D, Hashimoto K, Shimizu E, Fujisaki M, Iyo M. Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects. Neuropsychobiology. 2005;52(2):68-70.
  6. Shimizu E, Hashimoto K, Ochi S, Fukami G, Fujisaki M, Koike K, Okamura N,Ohgake S, Koizumi H, Matsuzawa D, Zhang L, Watanabe H, Nakazato M, Shinoda N,Komatsu N, Morita F, Iyo M. Posterior cingulate gyrus metabolic changes inchronic schizophrenia with generalized cognitive deficits. J Psychiatr Res. 2007;41(1-2):49-56.
  7. Ohgake S, Hashimoto K, Shimizu E, Koizumi H, Okamura N, Koike K, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Shirayama Y, Iyo M. Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis. Addict Biol. 2005;10(2):145-8.
  8. Matsuzawa D, Hashimoto K, Miyatake R, Shirayama Y, Shimizu E, Maeda K, SuzukiY, Mashimo Y, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Hata A, Sawa A, Iyo M. Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis. Am J Psychiatry. 2007;164(7):1105-14.
  9. Hashimoto T, Shimizu E, Koike K, Orita Y, Suzuki T, Kanahara N, Matsuzawa D, Fukami G, Miyatake R, Shinoda N, Fujisaki M, Shirayama Y, Hashimoto K, Iyo M.Deficits in auditory P50 inhibition in obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):288-96.
  10. Hashimoto T, Hashimoto K, Miyatake R, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M. Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2008;147B(7):1040-6.
  11. Matsuzawa D, Obata T, Shirayama Y, Nonaka H, Kanazawa Y, Yoshitome E, Takanashi J, Matsuda T, Shimizu E, Ikehira H, Iyo M, Hashimoto K. Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study. PLoS One. 2008 Apr 9;3(4):e1944.
  12. Kanahara N, Shimizu E, Ohgake S, Fujita Y, Kohno M, Hashimoto T, Matsuzawa D, Shirayama Y, Hashimoto K, Iyo M. Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801. Psychopharmacology (Berl). 2008;198(3):363-74.
  13. Matsuzawa D, Hashimoto K, Hashimoto T, Shimizu E, Watanabe H, Fujita Y, Iyo M. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2009 ;150B(1):86-94.
  14. Kurayama T, Nakazawa K, Matsuzawa D, Yoshida S, Nanbu M, Suto C, Shimizu E. Alterations of auditory p50 suppression in human fear conditioning and extinction. Biol Psychiatry. 2009;65(6):495-502.
  15. Ohgake S, Shimizu E, Hashimoto K, Okamura N, Koike K, Koizumi H, Fujisaki M, Kanahara N, Matsuda S, Sutoh C, Matsuzawa D, Muramatsu H, Muramatsu T, Iyo M. Dopaminergic hypofunctions and prepulse inhibition deficits in mice lacking midkine. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(3):541-6.
  16. Shirayama Y, Obata T, Matsuzawa D, Nonaka H, Kanazawa Y, Yoshitome E, Ikehira H, Hashimoto K, Iyo M. Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study. Neuroimage. 2010;49(3):2783-90.
  17. Ishii D, Matsuzawa D, Fujita Y, Sutoh C, Ohtsuka H, Matsuda S, Kanahara N, Hashimoto K, Iyo M, Shimizu E. Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after contextual fear extinction. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(1):183-8
  18. Nanbu M, Kurayama T, Nakazawa K, Matsuzawa D, Komiya Z, Haraguchi T, Ogura H, Hashimoto T, Yoshida S, Iyo M, Shimizu E. Impaired P50 suppression in fear extinction in obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):317-22.
  19. Ishii D, Matsuzawa D, Kanahara N, Matsuda S, Sutoh C, Ohtsuka H, Nakazawa K, Kohno M, Hashimoto K, Iyo M, Shimizu E. Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway. Neurosci Lett. 2010;471(1):53-7.
  20. Matsuda S, Matsuzawa D, Nakazawa K, Sutoh C, Ohtsuka H, Ishii D, Tomizawa H, Iyo M, Shimizu E. d-serine enhances extinction of auditory cued fear conditioning via ERK1/2 phosphorylation in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(6):895-902.
  21. Takasugi J, Matsuzawa D, Murayama T, Nakazawa K, Numata K, Shimizu E.Referred sensations induced by a mirror box in healthy subjects. Psychol Res.2011;75(1):54-60.
  22. Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M. Enhanced carbonyl stress in a subpopulation of schizophrenia. Arch Gen Psychiatry. 2010;67(6):589-97.
  23. Nakamura K, Enomoto H, Hanajima R, Hamada M, Shimizu E, Kawamura Y, Sasaki T, Matsuzawa D, Sutoh C, Shirota Y, Terao Y, Ugawa Y. Quadri-pulse stimulation (QPS) induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene. Neurosci Lett. 2011;487(3):264-7.
  24. Bannai M, Kawai N, Nagao K, Nakano S, Matsuzawa D, Shimizu E. Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats. Psychiatry Clin Neurosci. 2011;65(2):142-9.
  25. Matsuzawa D, Takeda K, Ohtsuka H, Takasugi J, Watanabe T, Maeda J, Nagakubo S, Sutoh C, Shimoyama I, Nakazawa K, Shimizu E. Correlation of prefrontal activity measured by near-infrared spectroscopy (NIRS) with mood, BDNF genotype and serum BDNF level in healthy individuals. Open Journal of Psychiatry, 2012, 2, 194-203.
  26. Kawai N, Bannai M, Seki S, Koizumi T, Shinkai K, Nagao K, Matsuzawa D,Takahashi M, Shimizu E. Pharmacokinetics and cerebral distribution of glycine administered to rats. Amino Acids. 2012;42(6):2129-37.
  27. Niitsu T, Shirayama Y, Matsuzawa D, Hasegawa T, Kanahara N, Hashimoto T, Shiraishi T, Shiina A, Fukami G, Fujisaki M, Watanabe H, Nakazato M, Asano M, Kimura S, Hashimoto K, Iyo M. Associations of serum brain-derived neurotrophicfactor with cognitive impair ments and negative symptoms in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(8):1836-40.
  28. Kurayama T, Matsuzawa D, Komiya Z, Nakazawa K, Yoshida S, Shimizu E. P50 suppression in human discrimination fear conditioning paradigm using danger and safety signals. Int J Psychophysiol. 2012;84(1):26-32.
  29. Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E. No erasure effect of retrieval-extinction trial on fear memory in the hippocampus-independent and dependent paradigms. Neurosci Lett. 2012;523(1):76-81.
  30. Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Nakazawa K, Amano K, Sajiki J, Shimizu E. Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39(2):273-9.
  31. Kurayama T, Tadokoro Y, Fujimoto S, Komiya Z, Yoshida S, Chakraborty S, Matsuzawa D, Shimizu E, Kondo K, Otaka Y. A comparison of the movement characteristics between the kneeling gait and the normal gait in healthy adults. Gait Posture. 2013 Mar;37(3):402-7.
  32. Sutoh C, Nakazato M, Matsuzawa D, Tsuru K, Niitsu T, Iyo M, Shimizu E. Changes in self-regulation-related prefrontal activities in eating disorders: a near infrared spectroscopy study. PLoS One. 2013;8(3):e59324.
  33. Tomizawa H, Matsuzawa D, Matsuda S, Ishii D, Sutoh C, Shimizu E. A Transient Fear Reduction by Pair-Exposure with a Non-Fearful Partner during Fear Extinction Independent from Corticosterone Level in Mice J.Behav.Brain.Sci. 2013;3:415-721.
  34. Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sajiki J, Shimizu E. Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice. Horm Behav. 2013;63(5):709-16.
  35. Niitsu T, Ishima T, Yoshida T, Hashimoto T, Matsuzawa D, Shirayama Y, Nakazato M, Shimizu E, Hashimoto K, Iyo M. A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia. Psychiatry Res. 2014;215(2):268-73.
  36. Niitsu T, Shirayama Y, Matsuzawa D, Shimizu E, Hashimoto K, Iyo M. Association between serum levels of glial cell-line derived neurotrophic factor and attention deficits in schizophrenia. Neurosci Lett. 2014;575:37-41.
  37. Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Shimizu E. Effects of memory age and interval of fear extinction sessions on contextual fear extinction. Neurosci Lett. 2014;578:139-42.
  38. Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E. Methyl donor-deficient diet during development can affect fear and anxieulthood in C57BL/6J mice. PLoS One. 2014 Aug 21;9(8):e105750
  39. Tomizawa H, Matsuzawa D, Ishii D, Matsuda S, Kawai K, Mashimo Y, Sutoh C, Shimizu E. Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus. Genes Brain Behav. 2015;14(3):301-9.
  40. Sutoh C, Matsuzawa D, Hirano Y, Yamada M, Nagaoka S, Chakraborty S, Ishii D, Matsuda S, Tomizawa H, Ito H, Tsuji H, Obata T, Shimizu E. Transient contribution of left posterior parietal cortex to cognitive restructuring. Sci Rep. 2015;17;5:9199.
  41. Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E. An isolated retrieval trial before extinction session does not prevent the return of fear. Behav Brain Res. 2015;287:139-45.
  42. Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Shimizu E. Sex differences in fear extinction and involvements of extracellular signal-regulated kinase (ERK). Neurobiol Learn Mem. 2015;123:117-24.
  43. Terada H, Kurayama T, Nakazawa K, Matsuzawa D, Shimizu E. Transcranial direct current stimulation (tDCS) on the dorsolateral prefrontal cortex alters P50 gating. Neurosci Lett. 2015;602:139-44.
  44. Sutoh C, Koga Y, Kimura H, Kanahara N, Numata N, Hirano Y, Matsuzawa D, Iyo M, Nakazato M, Shimizu E. Repetitive Transcranial Magnetic Stimulation Changes Cerebral Oxygenation on the Left Dorsolateral Prefrontal Cortex in Bulimia Nervosa: A Near-Infrared Spectroscopy Pilot Study. Eur Eat Disord Rev. 2016;24(1):83-8.
  45. Okuda T, Asano K, Numata N, Hirano Y, Yamamoto T, Tanaka M, Matsuzawa D, Shimizu E, Iyo M, Nakazato M. Feasibility of cognitive remediation therapy for adults with autism spectrum disorders: a single-group pilot study. Neuropsychiatr Dis Treat. 2017;13:2185-2191.
  46. Setsu R, Hirano Y, Tokunaga M, Takahashi T, Numata N, Matsumoto K, Masuda Y, Matsuzawa D, Iyo M, Shimizu E, Nakazato M. Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa. Front Psychiatry. 2017 25;8:172.
  47. 佐二木順子, 松田真悟, 松澤大輔, 清水栄司. ビスフェノールAの周産期暴露動物は発達障害および精神疾患のモデルとなりうるか？—行動ならびに脳内モノアミン代謝からみた考察— 子どものこころと脳の発達 2013 第4巻1号; 42-52.
  48. 濱田裕幸, 松澤大輔, 平野好幸, 須藤千尋, 清水栄司, 小畠隆行. 運動イメージと機能的MRI（fMRI）映像情報メディア学会誌 2013; 67(11), 944-948.
  49. 大渓 俊幸, 須藤 千尋, 松澤 大輔, 浅野 憲一, 野口 玲美, 磯田 洋美, 加藤 文, 吉田 智子, 生稲 直美, 鍋田 満代, 岩倉 かおり, 千勝 浩美, 近藤 妙子, 土屋 美香, 今井 千恵, 横地 紀子, 内 玲往那, 太和田 暁之, 吉田 知彦, 藤本 浩司, 潤間 励子, 中川 彰子, 中里 道子, 清水 栄司, 今関 文夫 新しい学生健康診断システムにおけるメンタルヘルス問診の試み CAMPUS HEALTH (1341-4313)53巻1号: 311-312, 2016

症例報告

  1. Matsuzawa D, Shirayama Y, Shimizu E, Hashimoto K, Iyo M. Evaluating the cognitive decline in early-stage frontotemporal dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(6):1077-9.
  2. Ohtsuka H, Matsuzawa D, Ishii D, Shimizu E. Longitudinal Follow-Up of Mirror Movements after Stroke: A Case Study. Case Rep Neurol Med. 2015:354134.
  3. 高杉潤, 沼田憲治, 松澤大輔, 中澤健, 清水栄司. ミラーボックスによって体性感覚脱失が一過性に改善した右被殻出血例. 神経心理学 2010;24164-170

総説

  1. Matsuzawa D, Hashimoto K. Magnetic resonance spectroscopy study of the antioxidant defense system in schizophrenia. Antioxid Redox Signal. 2011;15(7):2057-65
  2. 松澤大輔, 清水栄司. 認知行動療法の生物学的基盤-特に不安障害のCBTの生物学的基盤 日本生物学的精神医学会誌2012;23(3): 185-191.
  3. 松田真悟, 松澤大輔, 清水栄司. 恐怖の性差：疫学・画像・動物研究から. 不安障害研究. 2013. 第5巻 1号; 22-30.
  4. 平野好幸, 須藤千尋, 松澤大輔, 清水英司. 気になる脳部位 水道周囲灰白質 分子精神医学 13巻2号40-44
  5. 松澤大輔, 中川彰子【自閉症の分子基盤】強迫と自閉 分子精神医学(1345-9082)14巻2号 Page104-111(2014.04)
  6. 中里道子, 平野好幸, 松澤大輔, 松本有貴, 高岡昂太, 浅野憲一, 小畠隆行, 中川彰子, 清水栄司. 千葉大学大学院医学研究院子どものこころの発達研究センターについて 子どものこころと脳の発達. 第4巻1号 2013 26-33.
  7. 松澤大輔 不安とエピジェネティクス 心身医学56(4):333−39.2016

特別講演・シンポジウム

  1. 第55回全国大学保健管理協会関東甲信越地方部会 シンポジウム2「メンタル不調者の早期発見と支援」演題「社交不安の学生への認知行動療法」千葉市文化センター 千葉県千葉市 2017/9/1
  2. 第23回日本時間生物学会 シンポジウム 3「精神疾患の病態研究〜リズムと睡眠」Anxiety related mental illness and epigenetics名古屋大学豊田講堂 名古屋 2016/11/13
  3. 第22回日本行動医学会学術大会 シンポジウム「心身医学的ストレス研究の最前線:基礎から臨床まで」演題「ストレス関連精神疾患とエピジェネティクス」 東北大学医学部艮陵会館、宮城県仙台市 2015/10/16
  4. 第56回日本心身医学会総会 シンポジウム「ストレス調節のメカニズムとエピジェネティクス」演題「不安とエピジェネティクス」タワーホール船堀 東京都江戸川区 2015/6/26
  5. 第7回日本不安症学会 シンポジウム「不安の生物学的研究の最前線」演題「不安症とエピジェネティクス」アステールプラザ 広島県広島市 2015/2/15
  6. 第33回日本生物学的精神医学会 シンポジウム 「心理社会的治療の生物学的基盤」認知行動療法の生物学的基盤 ホテル グラン・パシフィック 東京都港区2011/5/21
  7. 第10回日本認知療法学会シンポジウム 「認知療法と生物学的要因」「恐怖消去とCBT」 大阪国際会議場 大阪府大阪市 2011/10/1

学会発表

  1. Matsuda S, Sutoh C, Ishii D, Tomizawa H, Matsuzawa D, Nakazawa K, Sajiki J, Shimizu E.. Effects of perinatal exposure to low dose of bisphenol A on anxiety behavior, monoamines, and activity of MAO in the male mice 第40回 NEUROSCIENCE 2010 San Diego Convention Center 2010/11/13
  2. Ishii D, Matsuzawa D, Sutoh C, Matsuda S, Tomizawa H, Shimizu E. Effects of methionine, choline and folic acid-deficient diet at the developmental period on anxiety and fear in mice 第40回 NEUROSCIENCE 2010 San Diego Convention Center 2010/11/13
  3. Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E. Effect of brain development during adolescence on recovery of fear Society for Neuroscience 42th Annual Meeting New Orleans 2012/10
  4. Tomizawa H, Matsuzawa D, Ishii D, Matsuda S, Sutoh C, Shimizu E. Effects of methyl donors deficient diet on cognitive functions Society for Neuroscience 42th Annual Meeting New Orleans 2012/10/15
  5. Sutoh C, Matsuzawa D, Hirano Y, Chakraborty S, Tomizawa H, Ishii D, Matsuda S, Obata T, Shimizu E. A dynamic fMRI study of restructuring cognitive schema for dirtiness. Society for Neuroscience 42th Annual Meeting New Orleans 2012/10/13-10/17
  6. Numata N, Sutoh C, Matsuzawa D, Hirano Y, Nakazato M, Shimizu E. Negative emotional states affect physiological conditions and performance during cognitive tasks in bulimia nervosa: a near-infrared spectroscopy study. 2014 International Conference on Eating Disorders. New York 2014/3/27-3/29
  7. Sahara Y, Matsuzawa D, Watanabe S, Ishii D, Matsuda S, Sutoh C, Shimizu E. Transgenerational effects of methyl donors deficient diets in mice: paternal methyl donors deficient diets during development can affect fear susceptibility in male offspring mice 第38回日本神経科学大会 神戸国際会議場 2015/7/29
  8. Sahara Y, Matsuzawa D, Fuchida T, Goto T, Suto C, Shimizu E. Transgenerational effects of methyl donors deficient diets in mice during juvenile period, The 40th Annual Meeting of Japan Neuroscience Society, Makuhari Messe, Chiba 2017/7/20
  9. 松澤大輔,橋本謙二,宮武良輔,白山幸彦,清水栄司,前田和久,鈴木洋一,真下陽,関根吉統,稲田俊也,尾崎紀夫,岩田仲生,野原睦生,小宮山徳太郎,山田光男,曽良一郎,氏家寛,羽田明,澤明,伊豫雅臣. ＰＩＣＫ１機能的遺伝子多型と覚せい剤精神病との関連 第34回日本脳科学会 出雲大社・研修館 2007/6/8
  10. 富澤 はるな, 松澤 大輔, 石井 大典, 松田 真悟, 河合 琴美, 須藤 千尋, 清水 栄司. 発達期のメチルドナー欠乏は記憶とAMPA受容体遺伝子の発現に影響する 第37回日本神経科学大会 横浜 2014/9/11-13

科研費取得

  1. 若手研究(B) 「画像解析と遺伝子解析を用いた強迫性障害病態へのグルタミン酸の役割に対しての研究」研究代表者 2008-2009
  2. 若手研究(B) 「発達期脳内DNAメチル化再編成がもたらす成長後のストレス耐性への影響」研究代表者 2012-2013
  3. 基盤研究(C) 「脳DNAメチル化再編の次世代への継承と生化学的環境変化」研究代表者2014-2016
  4. 基盤研究(C) 研究代表者 2017-2019

研究費取得

  1. 浦上財団 マウス発達期におけるメチルドナー不足がもたらす海馬に関連した記憶行動とエピジェネティックな変化について 研究代表者 2013
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